248.Qiuyan Zhang#, Sujing Xu#, Jianchang Qian#, Libin Yang, Pengqin Chen, Yi Wang, Xiang Hu, Yali Zhang, Wu Luo*, Guang Liang*. Pharmacological inhibition of MyD88 suppresses inflammation in tubular epithelial cells and prevents diabetic nephropathy in experimental mice. Acta Pharmacologica Sinica,2021, Accepted. (一区，IF= 6.15）[暂无下载] 247. Yali Zhang#,*, Wenxin Zhang#, Jueqian Yan#, Yelin Tang, Wenjing Jia, Zhengwei Xu, Mingjiang Xu, Nipon Chattipakorn, Yi Wang, Jianpeng Feng, Zhiguo Liu*, Guang Liang*. Chalcone derivatives ameliorate lipopolysaccharide-induced acute lung injury and inflammation by targeting MD2. Acta Pharmacologica Sinica,2021, Accepted. (一区，IF= 6.15）[暂无下载] 246.Jianqiang Chen, Xiangxiang Jin, Yanan Mei, Zhe Shen, Jufan Zhu, Hongyi Shi, Minshan Wang, Xiaohui Zheng*, Guang Liang*. The different biological effects of TMPyP4 and cisplatin in the inflammatory microenvironment of osteosarcoma are attributed to G-quadruplex. Cell Proliferation,2021, Accepted. (二区，IF= 6.83）[暂无下载] 245. Weixin Zhao, Yixiao Yan, Zhongxiang Xiao, Meihong Wang, Mingjiang Xu, Zhe Wang, Yi Wang, Zaishou Zhuang, Daona Yang, Gaozhi Chen*, Guang Liang*. Bicyclol Ameliorates Nonalcoholic Fatty Liver Disease in Mice via Inhibiting MAPKs and NF-κB Signaling Pathways. Biomedicine Pharmacotherapy,2021,141:111874. (二区，IF= 6.53）[PDF DOWNLOAD] 244. Jianchang Qian#, Sihui Yin#, Lin Ye, Zhe Wang, Sheng Shu, Zhenxing Mou, Mingjiang Xu, Nipon Chattipakorn, Zhiguo Liu*, Guang Liang*. An indole-2-carboxamide derivative, LG4, alleviates diabetic kidney disease through inhibiting MAPK-mediated inflammatory responses. Journal of Inflammation Research,2021,14:1633-1645. (二区，IF= 6.92）[PDF DOWNLOAD] 243. Shushi Huang#, Wu Luo#, Gaojun Wu, Qirui Shen, Zaishou Zhuang, Daona Yang, Jinfu Qian, Xiang Hu, Yan Cai, Nipon Chattipakorn, Weijian Huang*, Guang Liang*. Inhibition of CDK9 attenuates atherosclerosis by inhibiting inflammation and phenotypic switching of vascular smooth muscle cells. Aging-US,2021, 13(11):14892-14909. (二区，IF= 5.68）[PDF DOWNLOAD] 242. Dezhong Wang#, Yuan Yin#, Shuyi Wang#, Tianyang Zhao#, Fanghua Gong, Yushuo Zhao, Beibei Wang, Yuli Huang, Zizhao Cheng, Guanghui Zhu, Zengshou Wang, Yang Wang, Jun Ren, Guang Liang*, Xiaokun Li*, Zhifeng Huang*. FGF1ΔHBS prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression. Signal Transduction and Targeted Therapy,2021, 6(1):133. (一区，IF= 18.82）[PDF DOWNLOAD] 241. Shiju Ye# , Ke Lin#, Gaojun Wu, Ming-Jiang Xu, Peiren Shan, Weijian Huang*, Yi Wang*, Guang Liang*. Toll-like receptor 2 signaling deficiency in cardiac cells ameliorates Ang II-induced cardiac inflammation and remodeling. Translational Research,2021, 233:62-76. (一区，IF= 7.01）[PDF DOWNLOAD] 240. Xiaojing Yang#, Wu Luo#, Li Li#, Xiang Hu, Mingjiang Xu, Yi Wang, Jianpeng Feng, Jianchang Qian, Xinfu Guan, Yunjie Zhao*, Guang Liang*. CDK9 inhibition improves diabetic nephropathy by reducing inflammation in the kidneys. Toxicology and Applied Pharmacology,2021, 416:115465. (二区，IF= 4.21）[PDF DOWNLOAD] 239. Huaicheng Chen#, Tao Yan#, Zongming Song#, Shilong Ying, Beibei Wu, Xin Ju1, Xi Yang, Jia Qu, Wencan Wu, Zongduan Zhang, Yi Wang*. MD2 blockade prevents modified LDL-induced retinal injury in diabetes by suppressing NADPH oxidase-4 and its interaction with toll-like receptor-4. Experimental Molecular Medicine,2021, 53:681-694. (二区，IF= 8.72）[PDF DOWNLOAD] 238. Lin Ye, Xueting Hu, Xiang Hu, Sihui Yin, Hanghui He, Shanshan Hong, Bin Yang, Krishna K. Singh, Jianpeng Feng, Yi Wang, Wu Luo*, Guang Liang*. Curcumin Analogue C66 Attenuates Obesity-induced Renal Injury by inhibiting Chronic Inflammation. Biomedicine Pharmacotherapy,2021, 137:111418. (二区，IF= 6.53）[PDF DOWNLOAD] 237. Jinfu Qian#, Wu Luo#, Chengyi Dai, Jun Wang, Xinfu Guan, Nipon Chattipakorn, Gaojun Wu, Weijian Huang*, Guang Liang*. Myeloid differentiation protein 2 mediates angiotensin II-induced inflammation and mesenchymal transition in vascular endothelium. BBA - Molecular Basis of Disease,2021, 1867(3):166043. (一区，IF= 5.19）[PDF DOWNLOAD] 236. Wu Luo#, Xiaojun Chen#, Lin Ye#, Xuemei Chen#, Wenjing Jia, Yanni Zhao, Aleksandr V.Samorodov, Yali Zhang, Xueting Hu, Fei Zhuang, Jianchang Qian, Chao Zheng, Guang Liang*, Yi Wang*. Kaempferol attenuates streptozotocin-induced diabetic nephropathy by downregulating TRAF6 expression: the role of TRAF6 in diabetic nephropathy. Journal of Ethnopharmacology,2021, 268:113553. (一区，IF= 4.36）[PDF DOWNLOAD] 235. Ke Lin, Wu Luo, Jueqian Yan, Siyuan Shen, Qirui Shen, Jun Wang, Xinfu Guan, Gaojun Wu, Weijian Huang*, Guang Liang*. TLR2 regulates angiotensin II-induced vascular remodeling and EndMT through NF-κB signaling. Aging-US,2021, 13:2553-2574. (二区，IF= 5.68）[PDF DOWNLOAD] 234. Shushi Huang#, Shengban You#, Jinfu Qian, Chengyi Dai, Siyuan Shen, Jun Wang, Weijian Huang, Guang Liang*, Gaojun Wu*. Myeloid differentiation 2 deficiency attenuates AngII-induced arterial vascular oxidative stress,inflammation, and remodeling. Aging-US,2021, 13:4409-4427. (二区，IF= 5.68）[PDF DOWNLOAD] 233. Li Li#, Chunyong Ding#, Chunpeng Zou, Zhi Xiong, Weiwei Zhu, Jianchang Qian, Mingjiang Xu, Ao Zhang*, Guang Liang*. A novel salviadione derivative, compound 15a, attenuates diabetes-induced renal injury by inhibiting NF-κB-mediated inflammatory responses. Toxicology and Applied Pharmacology,2020, 409:115322. (二区，IF= 3.34）[PDF DONWLOAD] 232. Lingfeng Chen#，Lulu Zheng#，Pengqin Chen，Guang Liang*. Myeloid Differentiation Primary Response Protein 88 (MyD88): the central hub of TLR/IL-1R signaling. Journal of Medicinal Chemistry,2020, 63(22):13316-13329. (一区，IF= 6.2）[PDF DONWLOAD] 231. Xi Chen, Ying Zhao, Wu Luo, Sian Chen, Feng Lin, Xi Zhang, Shijie Fan, Xian Shen, Yi Wang*, Guang Liang*. Celastrol induces ROS-mediated apoptosis via directly targeting peroxiredoxin-2 in gastric cancer cells. Theranostics,2020, 10(22):10290-10308. (一区，IF= 8.58）[PDF DONWLOAD] 230. Xu Wang, Yi Wang, Victor Antony, Hongbin Sun*, Guang Liang*. Metabolism-Associated Molecular Patterns (MAMPs). Trends in Endocrinology and Metabolism,2020, 31(10):712-724. (一区，IF= 11.64）[PDF DOWNLOAD] 229. Xu Wang, Victor Antony, Yi Wang, Gaojun Wu, Guang Liang*. Pattern Recognition Receptor-mediated Inflammation in Diabetic Vascular Complications. Medicinal Research Reviews,2020, 40(6):2466-2484. (一区，IF= 9.3）[PDF DOWNLOAD] 228. Yi Wang#,*, Wu Luo#, Jibo Han#, Zia A. Khan, Qilu Fang, Yiyi Jin, Xuemei Chen, Yali Zhang, Meihong Wang, Jianchang Qian, Weijian Huang, Hazel Lum, Gaojun Wu, Guang Liang*. MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy. Nature Communications,2020, 11(1):2148. (一区，IF= 12.0）[PDF DOWNLOAD] 227. Chengguang Zhao#, Lehe Yang#, Feng Zhou#, Yun Yu, Xiaojing Du, Youqun Xiang, Chenglong Li, Xiaoying Huang, Congying Xie, Zhiguo Liu, Jiayuh Lin, Liangxing Wang*, Guang Liang*, Ri Cui*. Feedback activation of EGFR is the main cause for STAT3 inhibition-irresponsiveness in pancreatic cancer cells. Oncogene,2020, 39(20):3997-4013. (一区，IF= 6.6）[PDF DOWNLOAD] 226. Shiju Ye#, Wu Luo#, Zia A. Khan#, Gaojun Wu, Lina Xuan, Peiren Shan, Ke Lin, Taiwei Chen, Jingying Wang, Xiang Hu, Shengjie Wang, Weijian Huang*, Guang Liang*. Celastrol Attenuates Angiotensin II-induced Cardiac Remodeling by Targeting STAT3. Circulation Research,2020, 126(8):1007-1023. (一区，IF= 15.862）[PDF DOWNLOAD] 225. Taiwei Chen#, Weijian Huang#, Jinfu Qian, Wu Luo, Peiren Shan, Yan Cai, Ke Lin, Gaojun Wu*, Guang Liang*. Macrophage-derived myeloid differentiation protein 2 plays an essential role in ox-LDL-induced inflammation and atherosclerosis. EBioMedicine,2020, 53:102706. (一区，IF= 6.680）[PDF DOWNLOAD] 224. Vinoyhkumar Rajamanickam#, Tao Yan#, Shanmei Xu#,Junguo Hui, Xiaohong Xu, Liuqing Ren, Zhoudi Liu, Guang Liang, Ouchen Wang, Yi Wang*. Selective targeting of the TLR4 co-receptor, MD2, prevents colon cancer growth and metastasis. International Journal of Biological Sciences,2020, 16(8):1288-1302. (二区，IF= 4.067）[PDF DOWNLOAD] 223. Guang Liang#, Wei Meng#, Xiangjie Huang#, Wangyu Zhu, Changtian Yin, Canwei Wang, Matteo Fassan, Yun Yu, Masahisa Kudo,Sisi Xiao, Chengguang Zhao, Peng Zou, Yumin Wang, Xiaokun Li, Carlo M. Croce*, Ri Cui*. miR-196b-5p–mediated downregulation of TSPAN12 and GATA6 promotes tumor progression in non-small cell lung cancer. Proc Natl Acad Sci USA,2020, 117(8):4347-4357. (一区，IF= 9.6）[PDF DOWNLOAD] 222. Hui He#, Jie Guo#, Wei Sun, Bin Yang, Fengzhi Zhang*, Guang Liang*. Palladium-Catalyzed Direct Mono- or Polyhalogenation of Benzothiadiazole Derivat. Journal of Organic Chemistry,2020, 85(5):3788-3798. (二区，IF= 4.75）[PDF DOWNLOAD] 221. Lingfeng Chen, William M. Marsiglia, Huaibin Chen, Joseph Katigbak, Hediye Erdjument-Bromage, David J. Kemble, Lili Fu, Jinghong Ma, Gongqin Sun, Yingkai Zhang, Guang Liang, Thomas A. Neubert, Xiaokun Li, Nathaniel J. Traaseth* Moosa Mohammadi*. Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation. Nature Chemical Biology,2020, 16(3):267-277. (一区，IF= 12.154）[PDF DOWNLOAD] 220. Yali Zhang#, Hongjin Chen#, Wenxin Zhang#, Yan Cai, Peiren Shan, Di Wu, Bing Zhang, Hui Liu, Zia Khan, Guang Liang*. Arachidonic acid inhibits inflammatory responses by binding to myeloid differentiation factor-2 (MD2) and preventing MD2/toll-like receptor 4 signaling activation. BBA - Molecular Basis of Disease,2020, 1866(5):165683. (一区，IF= 4.328）[PDF DOWNLOAD] 219. Zengqiang Song#,*, Chaochao Ding#, Shaoli Wang#, Qian Dai, Yaoguang Sheng, Zhilong Zheng, Guang Liang*. Metal-Free Regioselective C–H Chalcogenylation of Coumarins/ (Hetero)Arenes at Ambient Temperature. Chemical Communications,2020, 56:1847-1850. (一区，IF= 6.164）[PDF DOWNLOAD] 218. Gaozhi Chen, Yuyan Bao, Qiaoyou Weng, Yingxin Zhao, Xiaoyao Lu, Lili Fu, Lingfeng Chen, Zhiguo Liu, Xiaomin Zhang and Guang Liang*. Compound 15c, a Novel Dual Inhibitor of EGFRL858R/T790M and FGFR1, Efficiently Overcomes Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance of Non-Small-Cell Lung Cancers. Frontiers in Pharmacology,2020, 10:1533. (二区，IF= 3.845）[PDF DOWNLOAD] 217. Ziheng Zhang#, Renyu Lin,#, Zhoudi Liu, Tao Yan, Yiqun Xia, Leping Zhao, Feng Lin, Xi Zhang, Chenglong Li, Yi Wang* . Curcumin analog, WZ37, promotes G2/M arrest and apoptosis of HNSCC cells through Akt/mTOR inhibition. Toxicology in Vitro,2020, 104754. (三区，IF= 3.067）[PDF DOWNLOAD] 216. Vinothkumar Rajamanickam#, Tao Yan#, Liangrong Wu, Yanni Zhao, Xiaohong Xu, Heping Zhu, Xi Chen, Meihong Wang, Zhoudi Liu, Zhiguo Liu, Guang Liang, Yi Wang*. Allylated curcumin analog CA6 inhibits TrxR1 and leads to ROS-dependent apoptotic cell death in gastric cancer through Akt-FoxO3a. Cancer Management and Research,2020, 12:247-263. (三区，IF= 2.243）[PDF DOWNLOAD] 215. Qianqian Zhang,Weiqian Chen,Xiuling Lv,Qiaoyou Weng,Minjiang Chen,Ri Cui,Guang Liang*,Jiansong Ji*. Piperlongumine, a Novel TrxR1 Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cells by ROS-Mediated ER Stress. Frontiers in Pharmacology,2019, 10(11):848-848. (二区，IF= 3.845）[PDF DOWNLOAD] 214. Lihua Wang#, Canwei Wang#, Zheying Tao#, Liqian Zhao#, Zheng Zhu, Wencan Wu, Ye He, Hong Chen, Bin Zheng, Xiangjie Huang, Yun Yu, Linjun Yang, Guang Liang*, Ri Cui* and Tongke Chen*. Curcumin derivative WZ35 inhibits tumor cell growth via ROS-YAP-JNK signaling pathway in breast cancer. Journal of Experimental Clinical Cancer Research,2019, 38(1)：460. (二区，IF= 5.646）[PDF DOWNLOAD] 211. Xiaohong Xu, Vinothkumar Rajamanickam, Sheng Shu, Zhoudi Liu, Tao Yan, Jinxin He, Zhiguo Liu, Guilong Guo, Guang Liang, Yi Wang*. Indole-2-carboxamide derivative LG25 inhibits triple-negative breast cancer growth by suppressing Akt/mTOR/NF-κB signalling pathway. Drug Design, Development and Therapy,2019, 13：3539-3550. (三区，IF= 3.208）[PDF DOWNLOAD] 210. Chun Lu#, Bing Zhang#, Tingting Xu, Wenxin Zhang, Bin Bai, Zhongxiang Xiao, Liqin Wu, Guang Liang, Yali Zhang* , Yuanrong Dai*. Piperlongumine reduces ovalbumin-induced asthma and airway inflammation by regulating NF-κB activation. International Journal of Molecular Medicine,2019, 44:1855-1865. (三区，IF= 2.928）[PDF DOWNLOAD] 209. Hongjin Chen#, Yali Zhang#, Wenxin Zhang#, Hui Liu, Chuchu Sun, Bing Zhang, Bin Bai, Di Wu, Zhongxiang Xiao, Hazel Lum, Jianmin Zhou, Ruijie Chen*, Guang Liang*. Inhibition of myeloid differentiation factor 2 by baicalein protects against acute lung injury. Phytomedicine,2019, 63:152997. (一区，IF= 3.61）[PDF DOWNLOAD] 207. Shengban You#, Jianchang Qian#, Gaojun Wu#, Yuanyuan Qian, Zhengxian Wang, Taiwei Chen, Jingying Wang, Weijian Huang*, Guang Liang*. Schizandrin B attenuates angiotensin II induced Endothelial to Mesenchymal Transition in vascular endothelium by suppressing NF-κB activation. Phytomedicine,2019, 62:152955. (一区，IF= 3.61）[PDF DOWNLOAD] 205. Sujing Xu#, Wu Luo#, Xiaohong Xu, Yuanyuan Qian, Zheng Xu, Weihui Yu, Xiaoou Shan, Xinfu Guan, Hazel Lum, Huiping Zhou*, Yi Wang*. MD2 blockade prevents oxLDL-induced renal epithelial cell injury and protects against high fat diet-induced kidney dysfunction. Journal of Nutritional Biochemistry,2019, 70:47-55. (二区，IF= 4.414）[PDF DOWNLOAD] 204. Zhiguo Liu,#,* Lingfeng Chen#, Pengtian Yu, Yali Zhang, Bo Fang, Chao Wu, Wu Luo, Xianxin Chen, Chenglong Li, Guang Liang*. Discovery of 3-(indol-5-yl)-indazole derivatives as novel myeloid differentiation protein 2/toll-like receptor 4 antagonists for treatment of acute lung injury. Journal of Medicinal Chemistry,2019, 62(11):5453-5469. (Cover story)(一区，IF= 6.23）[PDF DOWNLOAD] 202. Yi Wang#,*, Qilu Fang#, Yiyi Jin#, Zhoudi Liu, Chunpeng Zou, Weihui Yu, Weixin Li, Xiaoou Shan, Ruijie Chen, Zia Khan, Guang Liang*. Blockade of myeloid differentiation 2 attenuates diabetic nephropathy by reducing activation of the renin-angiotensin system in mouse kidneys. British Journal of Pharmacology,2019, 176:2642–2657. (一区，IF= 6.81）[PDF DOWNLOAD] 201. Zheng Xu#, Chunpeng Zou#, Weihui Yu, Sujing Xu, Lan Huang, Zia Khan, Jingying Wang, Guang Liang*, Yi Wang*. Inhibition of STAT3 activation mediated by toll‐like receptor 4 attenuates angiotensin II‐induced renal fibrosis and dysfunction. British Journal of Pharmacology,2019, 176:2627–2641. (一区，IF= 6.81）[PDF DOWNLOAD] 199. Taiwei Chen# , Wu Luo#, Gaojun Wu, Lanlan Wu, Shushi Huang, Jieli Li, Jingying Wang, Xiang Hu, Weijian Huang*, Guang Liang*. A novel MyD88 inhibitor LM9 prevents atherosclerosis by regulating inflammatory responses and oxidative stress in macrophages. Toxicology and Applied Pharmacology,2019, 370:44-55. (二区，IF= 3.616）[PDF DOWNLOAD] 198. Zengqiang Song*,#, Yan Zhou#, Wenxin Zhang#, Lingling Zhan, Yuanzu Yu, Yuehui Chen, Wenjing Jia, Zhiguo Liu, Jianchang Qian, Yali Zhang, Chenglong Li, Guang Liang*. Base Promoted Synthesis of Novel Indole-Dithiocarbamate Compounds as Potential Anti-Inflammatory Therapeutic Agents for Treatment of Acute Lung Injury. Eur J Med Chem,2019, 171:54-65. (一区，IF= 4.816）[PDF DOWNLOAD] 197. Wu Luo#, Yiyi Jin#, Gaojun Wu, Weiwei Zhu, Yuanyuan Qian, Yali Zhang, Jieli Li, Aisong Zhu, Guang Liang*. Blockage of ROS and MAPKs-mediated inflammation via restoring SIRT1 by a new compound LF10 prevents type 1 diabetic cardiomyopathy. Toxicology and Applied Pharmacology,2019, 370:24-35. (二区，IF= 3.616）[PDF DOWNLOAD] 196. Jianchang Qian#, Xianxin Chen#, Sheng Shu#, Wenxin Zhang, Bo Fang, Xiaojing Chen, Yunjie Zhao*, Zhiguo Liu*, Guang Liang. Design and synthesis novel di-carbonyl analogs of curcumin (DACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI). Eur J Med Chem,2019, 167:414-425. (一区，IF= 4.816）[PDF DOWNLOAD] 195. Yunjie Zhao#, Yongkai Cao#, Huizhen Chen#, Fei Zhuang, Chao Wu, Goo Yoon, Weiwei Zhu, Ying Su, Suqing Zheng, Zhiguo Liu*, Seung Hoon Cheon*. Synthesis, biological evaluation, and molecular docking study of novel allyl-retrochalcones as a new class of protein tyrosine phosphatase 1B inhibitors. Bioorg Med Chem,2019, 27:963-977. (三区，IF= 2.881）[PDF DOWNLOAD] 194. Jianchang Qian#, Xuemei Chen#, Xiaojun Chen#, Chuchu Sun, Yuchen Jiang, Yuanyuan Qian, Yali Zhang, Zia Khan, Jianmin Zhou*, Guang Liang*, Chao Zheng*. Kaempferol reduces K63-linked polyubiquitination to inhibit nuclear factor-κB and inflammatory responses in acute lung injury in mice. Toxicology Letters,2019, 306:53-60. (二区，IF= 3.17）[PDF DOWNLOAD] 192. Li Li#, Wu Luo#, Yuanyuan Qian#, Weiwei Zhu, Jianchang Qian, Jieli Li, Yiyi Jin, Xuzhong Xu*, Guang Liang*. Luteolin protects against diabetic cardiomyopathy by inhibiting NF-κB-mediated inflammation and activating the Nrf2-mediated antioxidant responses. Phytomedicine,2019, 59:152774. (一区，IF= 3.6）[PDF DOWNLOAD] 190. Lingfeng Chen#, Hongjin Chen#, Pengqin Chen#, Wenxin Zhang, Chao Wu, Chuchu Sun, Wu Luo, Lulu Zheng, Zhiguo Liu, Guang Liang*. Development of 2-amino-4-phenylthiazole analogues to disrupt myeloid differentiation factor 88 and prevent inflammatory responses in acute lung injury. Eur J Med Chem,2019, 161:22-38. (一区，IF= 4.816）[PDF DOWNLOAD] 189. Beibei Wu#, Zhongxiang Xiao#, Wenxin Zhang#, Hongjin Chen, Hui Liu, Jialing Pan, Xiaohong Cai, Guang Liang, Bin Zhou*, Xiaoou Shan*, Yali Zhang*. A novel resveratrol-curcumin hybrid, a19, attenuates high fat diet-induced nonalcoholic fatty liver disease. Biomedicine Pharmacotherapy,2019, 110: 951-960. (三区，IF= 3.457）[PDF DOWNLOAD] 187. Xuanxuan Dai# Changtian Yin#, Yi Zhang, Guilong Guo, Chengguang Zhao, Ouchen Wang, Youqun Xiang, Xiaohua Zhang*, Guang Liang*. Osthole inhibits triple negative breast cancer cells by suppressing STAT3. Journal of Experimental Clinical Cancer Research,2018, 37(1):322. (二区，IF= 6.22）[PDF DOWNLOAD] 186. Chaochao Ding, Yuanzu Yu, Qiongli Yu, Zixin Xie, Yan Zhou, Jianmin Zhou*, Guang Liang*, Zengqiang Song*. NIS/TBHP induced regioselective selenation of (hetero) arenes via direct C-H functionalization. ChemCatChem,2018, 10:1-6. (二区，IF= 4.674）[PDF DOWNLOAD] 185. Yuanzu Yu#, Yan Zhou#, Zengqiang Song*, Guang Liang.An efficient t-BuOK promoted C3-chalcogenylation of indoles with dichalcogenides. Org Biomol Chem,2018, 16:4958-4962. (二区，IF= 3.423）[PDF DOWNLOAD] 184. Qinqin Xia#, Xiaodong Bao#, Chuchu Sun#, Di Wu, Xiaona Rong, Zhiguo Liu, Yugui Gu, Jianmin Zhou, Guang Liang*. Design, synthesis and biological evaluation of novel 2-sulfonylindoles as potential anti-inflammatory therapeutic agents for treatment of acute lung injury. Eur J Med Chem,2018, 160:120-132. (一区，IF= 4.816）[PDF DOWNLOAD] 183. Jibo Han#, Shiju Ye#, Chunpeng Zou, Taiwei Chen, Jingying Wang, Jieli Li, Liqin Jiang, Jianjiang Xu, Weijian Huang*, Yi Wang*, Guang Liang*. Angiotensin II causes biphasic STAT3 activation through TLR4 to initiate cardiac remodeling. Hypertension,2018, 72:1301-1311. (一区，IF= 6.823）[PDF DOWNLOAD] 182. Xuanxuan Dai#, Changtian Yin#, Guilong Guo, Yi Zhang, Chenguang Zhao, Jianchang Qian, Ouchen Wang, Xiaohua Zhang*, Guang Liang*. Schisandrin B exhibits potent anticancer activity in triple negative breast cancer by inhibiting STAT3. Toxicology and Applied Pharmacology,2018, 358:110-119. (二区，IF= 3.616）[PDF DOWNLOAD] 181. Zhen Wang#, Yali Zhang#, Daniel M. Pinkas#, Alice E. Fox, Jinfeng Luo, Huocong Huang, Shengyang Cui, Qiuping Xiang, Tingting Xu, Qiuju Xun, Dongsheng Zhu, Zhengchao Tu, Xiaomei Ren, Rolf A. Brekken, Alex N. Bullock, Guang Liang*, Ke Ding*, and Xiaoyun Lu*. Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2-a]pyrazin-3-ylethynyl)-4-isopropyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2. J Med Chem,2018, 61(17):7977-7990. (一区，IF= 6.253）[PDF DOWNLOAD] 180. Xuanxuan Dai#, Junru Zhang#, Guilong Guo, Yuepiao Cai, Ri Cui, Changtian Yin, Weidong Liu, Rajamanickam Vinothkumar, Tingting Zhang, Guang Liang*, Xiaohua Zhang*. A mono-carbonyl analog of curcumin induces apoptosis in drug-resistant EGFR-mutant lung cancer through the generation of oxidative stress and mitochondrial dysfunction. Cancer Management and Research,2018, 10:3069-3082. (二区，IF= 3.702）[PDF DOWNLOAD] 179. Xiaodong Bao, Xiaona Rong, Zhiguo Liu, Yugui Gu, Guang Liang*, Qinqin Xia*. Potassium tert-Butoxide-Mediated Metal-Free Synthesis of Sulfonamides from Sodium Sulfinates and N,N-Disubstituted Formamides. Tetrahedron Letters,2018, 59:2853-2858. (三区，IF= 2.125）[PDF DOWNLOAD] 178. Yiyi Jin#, Jianchang Qian#, Xin Ju, Xiaodong Bao, Li Li, Suqing Zheng, Xiong Chen, Zhongxiang Xiao, Xuemei Chen, Weiwei Zhu, Weixin Li, Wencan Wu*, Guang Liang*. Osthole protects against acute lung injury by suppressing NF-κB-dependent inflammation. Mediators of Inflammation,2018, 4934592. (三区，IF= 3.549）[PDF DOWNLOAD] 177. Xiaoping Yang*, Shiqing Wang, Yali Zhang, Guang Liang*, Ting Zhu, Lijie Zhang, Shaoming Huang*, Desmond Schipper and Richard A. Jones*. A self-assembling luminescent lanthanide molecular nanoparticle with potential for live cell imaging. Chemical Science,2018, 9:4630-4637. (一区，IF= 9.063）[PDF DOWNLOAD] 176. Jiansong Ji#, Weiqian Chen#, Weishuai Lian, Ruijie Chen, Jinqing Yang, Qianqian Zhang, Qiaoyou Weng, Zia Khan, Jie Hu, Xi Chen, Peng Zou, Xiaoming Chen*, Guang Liang*. (S)-Crizotinib Reduces Gastric Cancer Growth Through Oxidative DNA Damage and Triggers Pro-survival Akt Signal. Cell Death and Disease,2018, 9(6):660. (二区，IF= 5.638）[PDF DOWNLOAD] 175. Siyang Xiao#, Wenxin Zhang#, Hongjin Chen, Bo Fang, Yinda Qiu, Xianxin Chen, Lingfeng Chen, Sheng Shu, Yunjie Zhao*, Zhiguo Liu*, Guang Liang. Design, synthesis, and structure–activity relationships of 2-benzylidene-1-indanone derivatives as anti-inflammatory agents for treatment of acute lung injury. Drug Design, Development and Therapy,2018, 12: 887-899. (三区，IF= 2.935）[PDF DOWNLOAD] 174. Yali Zhang#, Zhiguo Liu#, Jianzhang Wu, Bin Bai, Hongjin Chen, Zhongxiang Xiao, Lingfeng Chen, Yunjie Zhao, Hazel Lum, Yi Wang, Hong Zhang*, Guang Liang*. New MD2 inhibitors derived from curcumin with improved anti-inflammatory activity. Eur. J Med. Chem,2018, 148: 291-305. (一区，IF= 4.816）[PDF DOWNLOAD] 173. Xuemei Chen#, Jianchang Qian#, Lintao Wang, Jieli Li, Yunjie Zhao, Jibo Han, Zia Khan, Xiaojun Chen, Jingying Wang*, Guang Liang*. Kaempferol attenuates hyperglycemia-induced cardiac injuries by inhibiting inflammatory responses and oxidative stress. Endocrine,2018, 60(1): 83-94. (二区，IF= 3.179）[PDF DOWNLOAD] 172. Gaozhi Chen#, Yang Liu#, Regina Goetz, Lili Fu, Seetharaman Jayaraman, Ming-Chang Hu, Orson W. Moe, Guang Liang, Xiaokun Li*, Moosa Mohammadi*. α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling.Nature,2018, 553(7689): 461-466. (一区，IF= 41.577)[PDF DOWNLOAD] 171. Lingfeng Chen, Weitao Fu,Lulu Zheng, Yi Wang*, Guang Liang*. Recent Progress in the Discovery of Myeloid Differentiation 2 (MD-2) Modulators for Inflammatory Diseases. Drug Discovery Today,2018, 23(6):1187-1202. (一区，IF= 6.848）[PDF DOWNLOAD] 170. Xiong Chen#, Weihui Yu#, Weixin Li#, Hailing Zhang, Weijian Huang, Jingying Wang, Weiwei Zhu, Qilu Fang, Chao Chen, Xiaokun Li*, Guang Liang*. An Anti-inflammatory Chalcone Derivative Prevents Heart and Kidney From Hyperlipidemia-induced Injuries by Attenuating Inflammation. Toxicology and Applied Pharmacology,2018, 338: 43-53. (二区，IF= 3.616）[PDF DOWNLOAD] 169. Huaicheng Chen#, Zongming Song#, Shilong Ying, Xi Yang, Wei Wu, Qiufan Tan, Xin Ju, Wencan Wu, Xin Zhang, Jia Qu*, Yi Wang*. Myeloid differentiation protein 2 induced retinal ischemia reperfusion injury via upregulation of ROS through a TLR4-NOX4 pathway. Toxicology Letters,2018, 282: 109-120. (二区，IF= 3.166）[ PDF DOWNLOAD] 168. Dandan Liang#, Hongjin Chen#, Leping Zhao#, Wenxin Zhang#, Jie Hu, Zhiguo Liu, Peng Zhong, Wei Wang, Jingying Wang, Guang Liang*. Inhibition of EGFR attenuates fibrosis and stellate cell activation in diet-induced model of nonalcoholic fatty liver disease. BBA - Molecular Basis of Disease,2018, 1864(1): 133-142. (二区，IF= 5.108）[PDF DOWNLOAD] 167. Weishan Zhuge, Ruijie Chen, Vladimir Katanaev, Xidan Dong, Khan Zia, Xiangwei Sun, Xuanxuan Dai, Miao Bao, Xian Shen*, Guang Liang*. Costunolide specifically binds and inhibits thioredoxin reductase 1 to induce apoptosis in colon cancer. Cancer Letters,2018, 412: 46-58. (二区，IF= 6.491）[PDF DOWNLOAD] 166. Qilu Fang#, Jingying Wang#, Yali Zhang#, Lintao Wang#, Weixin Li#, Jibo Han, Weijian Huang, Guang Liang*, Yi Wang*. Inhibition of myeloid differentiation factor-2 attenuates obesity-induced cardiomyopathy and fibrosis. BBA - Molecular Basis of Disease,2018, 1864(1): 252-262. (二区，IF= 5.108）[PDF DOWNLOAD] 165. 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Zhiguo Liu#, Longguang Tang#, Heping Zhu#, Tingting Xu, Chenyu Qiu, Suqing Zheng, Yugui Gu, Jianpeng Feng, Yali Zhang*, Guang Liang*. Design, synthesis and structure-activity relationship study of novel indole-2-carboxamide derivatives as anti-inflammatory agents for the treatment of sepsis.Journal of Medicinal Chemistry, 2016, 59(10):4637-50. (一区，IF= 5.589)[PDF DOWNLOAD] 110.Yali Zhang, Jianzhang Wu, Shilong Ying, Gaozhi Chen, Beibei Wu, Tingting Xu, Zhiguo Liu, Xing Liu, Lehao Huang, Xiaoou Shan, Yuanrong Dai, Guang Liang*. Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury.Scientific Reports, 2016, 6:25130. (二区，IF= 5.228)[PDF DOWNLOAD] 109. Weixin Li#, Qilu Fang#, Peng Zhong, Lingfeng Chen, Lintao Wang, Yali Zhang, Jun Wang, Xiaokun Li,Yi Wang, Jingying Wang*, Guang Liang*. EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice.Scientific Reports, 2016, 6: 24580. (二区，IF= 5.228)[PDF DOWNLOAD] 108. Wei Xu, Yangli Xie, Quan Wang, Xiaofeng Wang, Fengtao Luo, Siru Zhou, Zuqiang Wang, Junlan Huang, Qiaoyan Tan, Min Jin, Huabing Qi, Junzhou Tang, Liang Chen, Xiaolan Du, Chengguang Zhao, Guang Liang*, Lin Chen*. A novel fibroblast growth factor receptor 1 inhibitor protects against cartilage degradation in a murine model of osteoarthritis.Scientific Reports, 2016, 6: 24042. (二区，IF= 5.228)[PDF DOWNLOAD] 107. Jinming Zhang, Jie Hu, Hon Fai Chan, Melissa Skibba, Guang Liang*, Meiwan Chen*. iRGD Decorated Lipid-polymer Hybrid Nanoparticles for Targeted Co-delivery of Doxorubicin and Sorafenib to Enhance Anti-hepatocellular Carcinoma Efficacy.Nanomedicine, 2016, 12(5): 1303-11. (二区，IF= 5.417) 106. 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A novel imidazopyridine derivative, X22, attenuates sepsis-induced lung and liver injury by inhibiting the inflammatory response in vitro and in vivo.Drug Design, Development and Therapy, 2016, 10: 1947–1959. (三区，IF= 2.881)[PDF DOWNLOAD] 98. Qiaoyou Weng, Luqing Ren, Lu Guo, Yan Hu, Haixia Zhou, Yuyan Bao, Lingfeng Chen, Guang Liang, Yi Wang*, Jichen Ruan*. Curcumin analogue, A13, exhibits anti-leukemia effect via inhibiting STAT3.Tumor Biology, 2016, 37(7):9959-66. (三区，IF= 2.926) 97. Chengguang Zhao#, Huameng Li#, Huey-Jen Lin, Shulin Yang*, Jiayuh Lin* and Guang Liang. Feedback activation of STAT3 as a cancer drug-resistance mechanism.Trends Pharmacol Sci., 2016: 37 (1): 47-61. (一区，IF= 11.84)[PDF DOWNLOAD] 96. Yiqun Xia#, Bixia Weng#, Zhankun Wang, Yanting Kang, Lingyi Shi, Guanqun Huang, Shilong Ying, Xiaojing Du, Qiuxiang Chen, Rong Jin*, Jianzhang Wu*, Guang Liang. W346 inhibits cell growth, invasion, induces cycle arrest and potentiates apoptosis in human gastric cancer cells in vitro through the NF-κB signaling pathway.Tumor Biology, 2016, 37(4):4791-801. (三区，IF=2.926)[PDF DOWNLOAD] 95. Weitao Fu#, Lingfeng Chen#, Zhe Wang, Chengwei Zhao, Gaozhi Chen, Xing Liu, Yuanrong Dai, Yuepiao Cai, Chenglong Li, Jianmin Zhou*, Guang Liang*. Determination of the binding mode for anti-inflammatory natural product xanthohumol with myeloid differentiation protein 2.Drug Design, Development and Therapy, 2016, 10, 455-463. (三区，IF=2.881)[PDF DOWNLOAD] 94. Yuanyuan Qian#, Kesong Peng#, Chenyu Qiu, Melissa Skibba, Yi Huang, Zheng Xu, Yali Zhang, Jie Hu, Dandan Liang, Chunpeng Zou, Yi Wang, Guang Liang*. Novel EGFR inhibitor attenuates Ang II-induced Kidney Fibrosis.Journal of Pharmacology and Experimental Therapeutics, 2016, 356(1), 32-42. (二区，IF= 3.76)[PDF DOWNLOAD] 93. Kesong Peng#, Xinqiao Tian#, Yuanyuan Qian, Melissa Skibba, Chunpeng Zou, Zhiguo Liu, Jingying Wang, Zheng Xu, Xiaokun Li*, Guang Liang*. Novel EGFR inhibitors attenuate cardiac hypertrophy induced by angiotensin II.Journal of Cellular and Molecular Medicine, 2016, 20(3), 482-494. (二区，IF= 4.938)[PDF DOWNLOAD] 92. Peng Zou, Yiqun Xia, Tongke Chen, Junru Zhang, Zhe Wang, Wenbo Chen, Minxiao Chen, Karvannan Kanchana, Shulin Yang*, Guang Liang*. Selective killing of gastric cancer cells by a small molecule targeting ROS-mediated ER stress activation. Molecular Carcinogenesis, 2016, 55(6): 1073-1086. (二区, IF=4.722)[PDF DOWNLOAD] 91. Xu Shanmei, Chen Minxiao, Chen Wenbo, Hui Junguo, Ji Jiansong, Hu Shuping, Zhou Jianmin*, Wang Yi*, Liang Guang. Chemopreventive effect of chalcone derivative, L2H17, in colon cancer development.BMC Cancer, 2015, 15: 870. (三区，IF= 3.362)[PDF DOWNLOAD] 90. Xiuhua Zhang#, Minxiao Chen#, Peng Zou, Karvannan Kanchana, Qiaoyou Weng, Wenbo Chen, Peng Zhong, Jiansong Ji, Huiping Zhou, Langchong He*, Guang Liang*. Curcumin Analog WZ35 Induced Cell Death via ROS-dependent ER Stress and G2/M Cell Cycle Arrest in Human Prostate Cancer Cells.BMC Cancer, 2015, 15: 866. (三区，IF= 3.362)[PDF DOWNLOAD] 89. Lei Fan#, Wulan Li#, Shilong Ying, Lingyi Shi, Zhe Wang, Gaozhi Chen, Hui Ye, Xiaoping Wu*, Jianzhang Wu*, Guang Liang, Xiaokun Li. A peptide derivative serves as a fibroblast growth factor 2 antagonist in human gastric cancer.Tumor Biology, 2015, 36 (9), 7233-7241. (三区，IF=3.611)[PDF DOWNLOAD] 88. Qilu Fang#, Liancheng Deng#, Lintao Wang, Yali Zhang, Qiaoyou Weng, Haimin Yin, Yong Pan, Chao Tong, Jingying Wang, Guang Liang*.Inhibition of Mitogen-Activated Protein Kinases/Nuclear Factor kB–Dependent Inflammation by a Novel Chalcone Protects the Kidney from High Fat Diet–Induced Injuries in Mice.Journal of Pharmacology and Experimental Therapeutics, 2015, 355(2): 235-46. (二区，IF=3.972)[PDF DOWNLOAD] 87. Peng Zou, Minxiao Chen, Jiansong Ji, Weiqian Chen, Xi Chen, Shilong Ying, Junru Zhang, Ziheng Zhang, Zhiguo Liu, Shulin Yang*, Guang Liang*. Auranofin induces apoptosis by ROS-mediated ER stress and mitochondrial dysfunction and displayed synergistic lethality with piperlongumine in gastric cancer. Oncotarget, 2015, 6 (34): 36505-36521. (一区，IF=6.359)[PDF DOWNLOAD] 86. Qiaoyou Weng#, Lili Fu#, Gaozhi Chen, Junguo Hui, Jingjing Song, Jianpeng Feng, Dengjian Shi, Yuepiao Cai, Jiansong Ji*, Guang Liang*. Design, Synthesis, and Anticancer Evaluation of Long-chain Alkoxylated Mono-carbonyl Analogues of Curcumin. European Journal of Medicinal Chemistry, 2015, 103: 44-55. (二区, IF=3.447)[PDF DOWNLOAD] 85. Leping Zhao#, Yong Pan#, Kesong Peng, Zhe Wang, Jieli Li, Dan Li, Chao Tong*, Yi Wang*, Guang Liang. Inhibition of 11β-HSD1 by LG13 improves glucose metabolism in type 2 diabetic mice. Journal of Molecular Endocrinology, 2015, 55: 119-131. (三区, IF=3.08)PDF DOWNLOAD] 84. Qilu Fang, Jingying Wang, Lintao Wang, Yali Zhang, Haimin Yin, Yunzhou Li, Chao Tong, Guang Liang*, Chao Zheng*. Attenuation of inflammatory response by a novel chalcone protects kidney and heart from hyperglycemia-induced injuries in type 1 diabetic mice. Toxicology and Applied Pharmacology, 2015, 288: 179-191. (二区, IF=3.705)[PDF DOWNLOAD] 83. Lili Dong#, Suqing Zheng#, Yali Zhang, Xin Jiang, Jianzhang Wu, Xiaoqin Zhang, Xiaoou Shan, Dandan Liang, Shilong Ying, Jianpeng Feng* and Guang Liang*. Design, synthesis, and evaluation of semi-conservative mono-carbonyl analogs of curcumin as anti-inflammatory agents against lipopolysaccharide induced acute lung injury. MedChemComm, 2015, 6, 1544-1553. (三区, IF=2.495)[PDF DOWNLOAD] 82. Wenbo Chen#, Xiangting Ge#, Fengli Xu, Yali Zhang, Zhiguo Liu, Jialing Pan, Jiao Song, Yuanrong Dai, Jianmin Zhou*, Jianpeng Feng*, Guang Liang. Design, synthesis and biological evaluation of paralleled Aza resveratrol–chalcone compounds as potential anti-inflammatory agents for the treatment of acute lung injury. Bioorganic Medicinal Chemistry Letters, 2015, 25, 2998-3004. (三区, IF=2.42)[PDF DOWNLOAD] 81. Yi Wang#, Xiaoou Shan#, Gaozhi Chen, Lili Jiang, Zhe Wang, Qilu Fang, Xing Liu, Jingying Wang, Yali Zhang, Wencan Wu, Guang Liang*. MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis. British Journal of Pharmacology, 2015, 172(17): 4391-4405. (二区, IF=4.842)[PDF DOWNLOAD] 80. Zhe Wang#, Peng Zou#, Chenglong Li, Wenfei He, Bing Xiao, Qilu Fang, Wenbo Chen, Suqing Zheng, Yunjie Zhao*, Yuepiao Cai* and Guang Liang. Synthesis and biological evaluation of novel semi-conservative mono-carbonyl analogs of curcumin as anti-inflammatory agents. MedChemComm, 2015, 6, 1328-1339. (三区, IF=2.495)[PDF DOWNLOAD] 79. Jianzhang Wu, Zhijian Cai, XiaoyanWei, Minxiao Chen, Shilong Ying, Lingyi Shi, Ren-Ai Xu, Fan He, Guang Liang, and Xiuhua Zhang*. Anti-Lung Cancer Activity of the Curcumin Analog JZ534 In Vitro. BioMed Research International,2015: 504529(三区, IF=1.579).[PDF DOWNLOAD] 78. Jie Hu#, Yali Zhang#, Lili Dong, Zhe Wang, Lingfeng Chen, Dandan Liang, Dengjian Shi, Xiaoou Shan and Guang Liang*. Design, Synthesis, and Biological Evaluation of Novel Quinazoline Derivatives as Anti-inflammatory Agents against Lipopolysaccharide-induced Acute Lung Injury in Rats. chemical biology drug design, 2015, 85:672-684. (三区, IF=2.485)[PDF DOWNLOAD] 77. Weixin Li, Lintao Wang, Weijian Huang, Melissa Skibba, Qilu Fang, Longteng Xie, Tiemin Wei, Zhiguo Feng, Guang Liang*. Inhibition of ROS and inflammation by an imidazopyridine derivative X22 attenuates high fat diet-induced arterial injuries. Vascular Pharmacology, 2015, 72:153-162. (三区, IF=3.635)[PDF DOWNLOAD] 76. Zhe Wang#, Gaozhi Chen#, Lingfeng Chen, Xing Liu, Weitao Fu, Yali Zhang, Chenglong Li, Guang Liang* and Yuepiao Cai*. Insights into the binding mode of curcumin to MD-2: studies from molecular docking, molecular dynamics simulations and experimental assessments. Molecular BioSystems, 2015, 11,1933-1938. (三区, IF=3.21)[PDF DOWNLOAD] 75. Yang Bian#, Luqing Ren#, Lei Wang, Shanmei Xu, Jianjian Tao, Xiuhua Zhang, Yi Huang, Yuanyuan Qian, Xin Zhang, Zongming Song, Wencan Wu*, Yi Wang*, Guang Liang. A novel imidazopyridine derivative, X22, prevents the retinal ischemia-reperfusion injury via inhibition of MAPKs. Experimental Eye Research, 2015, 135: 26-36. 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Yali Zhang#, Dan dan Liang#, Lili Dong, Xiangting Ge, Fengli Xu, Wenbo Chen, Yuanrong Dai, Huameng Li, Peng Zou, Shulin Yang*, Guang Liang*. Anti-inflammatory effects of novel curcumin analogs in experimental acute lung injury.Respiratory Research, 2015, 16: 43. (二区，IF=3.093)[PDF DOWNLOAD] 70. Dan dan Liang#, Peng Zhong#, Jie Hu, Feng Lin, Yuanyuan Qian, Zheng Xu, Jingying Wang, Chunlai Zeng, Xiaokun Li, Guang Liang*. EGFR inhibition protects cardiac damageand remodeling through attenuating oxidative stress in STZ-induced diabetic mouse model.Journal of Molecularand Cellular Cardiology, 2015, 82: 63-74.[二区，IF=4.655，With a commentary in the same issue （Zheng Xu, Lu Cai. Diabetic cardiomyopathy: Role of epidermal growth factor receptor tyrosine kinase, Journal of Molecular Cellular Cardiology, 2015, 84: 10-12)[PDF DOWNLOAD] 69. Peng Zhong, Lianpin Wu, Yuanyuan Qian, Qilu Fang, Dandan Liang, Jingying Wang, Chunlai Zeng, Yi Wang *, Guang Liang*. Blockage of ROS and NF-kB-mediated inflammation by a new chalcone L6H9 protects cardiomyocytes from hyperglycemia-induced injuries.BBA - Molecular Basis of Disease, 2015, 1852: 1230-1241. (二区，IF=4.882)[PDF DOWNLOAD] 68. Chengguang Zhao#, Jianpeng Feng#, Mingming Zuo#, Jianfeng Zhao, Shanmei Xu, Suqing Zheng, Yali Zhang, Qinqin Tang, Zhongqiu Lu, Guang Liang*and Jianmin Zhou*. Synthesisand Biological Evaluation of Acetylenic Chalcones as Novel Anti-Inflammatory Agents. Med Chem, 2015, 11(6): 567-72. (四区，IF=1.402)[PDF DOWNLOAD] 67. Yuanyuan Qian#, Peng Zhong#, Dan dan Liang, Zheng Xu, Melissa Skibba, Chunlai Zeng, Xiaokun Li, Tiemin Wei, Lianpin Wu*, Guang Liang*. A newly designed curcumin analog Y20 mitigates cardiac injury via anti-inflammatoryand anti-oxidant actions in obese rats. Plos One, 2015, 10(3): e0120215. (三区，IF=3.234)[PDF DOWNLOAD] 66. Jianpeng Feng#, Bing Xiao#, Wenbo Chen, Ting Ding, Lingfeng Chen, Pengtian Yu, Fengli Xu, Huajie Zhang*, Zhiguo Liu*, Guang Liang.Synthesisand anti-inflammatory evaluation of novel C66 analogs for the treatment of LPS-induced acute lung injury. Chemical Biologyand Drug Design, 2015, Oct; 86(4): 753-63. (三区，IF=2.485)[PDF DOWNLOAD] 65. Peng Zou#, Junru Zhang, Yiqun Xia, Karvannan Kanchana, Guilong Guo, Wenbo Chen, Yi Huang, Zhe Wang, Shulin Yang*, Guang Liang*. ROS generation mediates the anti-cancer effects of WZ35 via activating JNKand ER stress apoptotic pathways in gastric cancer. Oncotarget, 2015, 6(8): 5860-5876. (一区，IF=6.359)[PDF DOWNLOAD] 64. Chaochao Xu#, Wulan Li#, Peihong Qiu, Yiqun Xia, Xiaojing Du, Fen Wang, Lailai Shen, Qiuxiang Chen, Yunjie Zhao, Jin Rong*, Jianzhang Wu*, Guang Liang, Xiaokun Li.The therapeutic potential of a novel non-ATP-competitive fibroblast growth factor receptor 1 inhibitor on gastric cancer. Anti-Cancer Drugs, 2015, 26(4): 379-87. 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Novel curcumin analogue 14p protects against myocardial ischemia reperfusion injury through Nrf2-activating anti-oxidative activity.Toxicologyand Applied Pharmacology,2015, 282(2):175-183. (二区，IF=3.705)[PDF DOWNLOAD] 60. Chunlai Zeng#, Peng Zhong#, Yunjie Zhao, Karvannan Kanchana, Yali Zhang, Zia A. Khan, Subrata Chakrabarti, Lianpin Wu, Jingying Wang, Guang Liang*. Curcumin protects hearts from FFA-induced injury by activating Nrf2and inactivating NF-κB both in vitroand in vivo. Journal of Molecularand Cellular Cardiology, 2015, 79, 1-12.(二区，IF=4.655)[PDF DOWNLOAD] 59. Qilu Fang#, Leping Zhao#, Yi Wang, Yali Zhang, Yong Pan, Karvannan Kanchana, Jingying Wang, Chao Tong, Dan Li*, Guang Liang*. A novel chalcone derivative attenuates the diabetes-induced renal injury via inhibition of high glucose-mediated inflammatory responseand macrophage infiltration. Toxicology and Applied Pharmacology, 2015, 282(2): 129-138.(二区，IF=3.705)[PDF DOWNLOAD] 58. 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Yi Wang#, Hui Wang, Luqing Ren, Qiaoyou Weng, Yuyan Bao, Haishan Tian, YongguangYang*, Xiaokun Li*. Non-mitogenic form of acidic fibroblast growth factor protects against graft-versus-host disease without accelerating leukemia.International Immunopharmacology, 2014, 23 (2): 395-9. (三区，IF=2.71)[PDF DOWNLOAD] 54. Yiqun Xia#, Xiaoyan Wei#, Wulan Li#, Karvannan Kanchana, Chaochao Xu, Dahui Chen, Peihong Chou, Rong Jin*, Jianzhang Wu*, Guang Liang. Curcumin Analogue A501 induces G2/M Arrestand Apoptosis in Non-small Cell Lung Cancer Cells.Asian Pacific Journal of Cancer Prevention, 2014, 15(16), 6893-6898. (四区，IF=1.50)[PDF DOWNLOAD] 53. Lei Fan#, Hang Xie#, Lingzi Chen#, Hui Ye, Shilong Ying, Cong Wang, Xiaoping Wu, Wulan Li*, Jianzhang Wu*, Guang Liang, Xiaokun Li. A novel FGF2 antagonist peptide P8 with potent antiproliferation activity, Tumor Biol, 2014,35(10):10571-9 . (三区，IF=2.52)[PDF DOWNLOAD] 52. Jianzhang Wu#, Jiansong Ji#, Bixia Weng, Peihong Qiu, Karvannan Kanchana, Tao Wei, Yi Wang, Yuepiao Cai, Xiaokun Liand Guang Liang*. Discovery of novel non-ATP competitive FGFR1 inhibitorsand evaluation of their anti-tumor activity in non-small cell lung cancer in vitroand in vivo, Oncotarget, 2014, 5(12), 4543-4553.(一区，IF=6.64)[PDF DOWNLOAD] 51. Yali Zhang#, Leping Zhao#, Jianzhang Wu#, Xin Jiang, Lili Dong, Fengli Xu, Yuanrong Dai, Peng Zou, Xiaoou Shan*, Shulin Yang*, Guang Liang. Synthesisand evaluation of a series of novel asymmetrical curcumin analogs for the treatment of inflammation, Molecules, 2014, 19(6), 7287-7307. (三区，IF=2.43)[PDF DOWNLOAD] 50. Pan Yong, Wang Yi, Zhao Yunjie, Peng Kesong, Li Weixin, Wang Yonggang, Zhang Jingjing, Zhou Shanshan, Liu Quan, Li Xiaokun, Cai Lu, Guang Liang*. Inhibition of JNK phosphorylation by a novel curcumin analog prevents high glucose-induced inflammationand apoptosis in cardiomyocytesand the development of diabetic cardiomyopathy, Diabetes, 2014, 63:3497–3511. [一区，IF=8.0，With a commentary in the same issue （Jun Ren, James R. Sowers. Application of a Novel Curcumin Analog in the Management of Diabetic Cardiomyopathy, Diabetes, 2014;63:3166–3168) ][PDF DOWNLOAD] 49. Yali Zhang#, Chengguang Zhao#, Wenfei He#, Zhe Wang, Qilu Fang, Bing Xiao, Zhiguo Liu, Guang Liang*, Shulin Yang*. Discoveryand evaluation of asymmetrical monocarbonyl analogs of curcumin as anti- inflammatory agents, Drug Design, Developmentand Therapy, 2014, 8: 373–382. (三区，IF=3.49)[PDF DOWNLOAD] 48. Yong Pan#, Yi Huang#, Zhe Wang, Qilu Fang, Yusheng Sun, Chao Tong, Kesong Peng, Yangwei Wang, Lining Miao, Lu Cai, Yunjie Zhao, Guang Liang*. 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Yong Pan#, Xiuhua Zhang#, Yi Wang#, Lu Cai, Luqing Ren, Longguang Tang, Jingying Wang, Yunjie Zhao, Yonggang Wang, Quan Liu, Xiaokun Li, Guang Liang*. Targeting JNK by a new curcumin analog to inhibit NF-kB-mediated expression of cell adhesion molecules attenuates renal macrophage infiltrationand injury in diabetic mice, Plos One, 2013, 8(11): e79084. (三区，IF=3.73)[PDF DOWNLOAD] 41. Yi Wang, Hui Wang, Jinxing Xia, Tingting Liang, Guanjun Wang, Xiaokun Li, Yong-Guang Yang*. Activated CD8 T cells acquire NK1.1 expressionand preferentially locate intheliver in mice after allogeneic hematopoietic cell transplantation. Immunol Lett, 2013, 150(1-2): 75-8. (三区，IF=2.34)[PDF DOWNLOAD] 40. Jianzhang Wu#, Yali Zhang#, Yuepiao Cai, Jian Wang, Bixia Weng, Qinqin Tang, Xiangjian Chen, Zheer Pan, Guang Liang*, Shulin Yang*. Discoveryandevaluation of piperid-4-one-containing mono-carbonyl analogs of curcumin as anti-inflammatory agents. Bioorganicand Medicinal Chemistry, 21 (2013) 3058–3065. 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Jian Xiao#, Yi Wang#, Jing Peng, Lu Guo, Jie Hu, Menghua Cao, Xie Zhang, Hanqing Zhang, Zhouguang Wang, Xiaokun Li, Shulin Yang, Huiling Yang, Guang Liang*. A synthetic compound, 1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one (B63), induces apoptosisand activates endoplasmic reticulum stress in non-small cell lung cancer cells. International Journal of Cancer, 2012, 131, 1455-65. (二区，IF = 6.20)[PDF DOWNLOAD] 31. Zhao Cheng-Guang#, Chen Xiao-Yan#, Hu Jie, Zhang Li, Zhao Yun-Jie, Yang Shu-Lin, Guang Liang*. Synthesisand Crystal Structure of Monocarbonyl Analogs of Curcumin. Chinese J. Struct. Chem, 2012, 31(4): 491-497. (四区，IF = 0.41)[PDF DOWNLOAD] 30. Wang Yi#, Yu Congcong#, Pan Yong, Yang Xuyi, Huang Yi, Feng Zhiguo, Li Xiaokun, Yang Shulin, Liang Guang*. A Novel Synthetic Mono-Carbonyl Analogue of Curcumin, A13, Exhibits Anti-Inflammatory Effects In vivo by Inhibition of Inflammatory Mediators, Inflammation. 2012, 35(2): 594-604. (四区，IF = 2.46)[PDF DOWNLOAD] 29. Jianzhang Wu#, Cong Wang#, Yuepiao Cai, Jing Peng, Donglou Liang, Yunjie Zhao, Shulin Yang, Xiaokun Li, Xiaoping Wu, Guang Liang*. Synthesisand crystal structure of chalcones as well as on cytotoxicityand antibacterial properties, Med Chem Res, 2012, 21: 444-452 (四区，IF = 1.61)[PDF DOWNLOAD] 28. Jianzhang Wu#, Jianling Li#, Yuepiao Cai, Yong Pan, Faqing Ye, Yali Zhang, Yunjie Zhao, Shulin Yang, Xiaokun Li, Guang Liang*. Evaluationand Discovery of Novel Synthetic Chalcone Derivatives as Anti-Inflammatory Agents. Journal of Medicinal Chemistry, 2011, 54(23), 8110-8123. (一区，IF = 5.61)[PDF DOWNLOAD] 27. Yi Wang#, Congcong Yu#, Yong Pan, Jianling Li, Yali Zhang, Faqing Ye, Shulin Yang, Hui Zhang, Xiaokun Li, Guang Liang*. A novel compound C12 inhibits inflammatory cytokine productionand protects from inflammatory injury in vivo, Plos One, 2011, 6(9): e24377. (二区，IF = 3.73)[PDF DOWNLOAD] 26. Yi Wang#, Jian Xiao#, Huiping Zhou, Shulin Yang, Xiaoping Wu, Chengxi Jiang, Yunjie Zhao, Donglou Liang, Xiaokun Li, Guang Liang*. A Novel Monocarbonyl Analogue of Curcumin, (1E,4E)-1,5-Bis 2 (2,3-dimethoxyphenyl)penta-1,4-dien-3-one, Induced Cancer Cell H460 Apoptosis via Activation of Endoplasmic Reticulum Stress Signaling Pathway, Journal of Medicinal Chemistry, 2011, 54(11): 3768-3778 (一区，IF = 5.61)[PDF DOWNLOAD] 25.Zhang Li#, Wang Hong#, Zhao Chengguang, Tang Qinqin, Xiong Wei, Cai Yuepiao, Chen Gaozhi, Hu Jie, Liang Guang*. Synthesisand Crystal Structure of (2E,6E)-2,6-Bis(2,3-dimethoxybenzylidene)cyclohexanone, Chinese J. Struct. Chem. 2011, 30 (2): 278-283. (四区，IF = 0.41)[PDF DOWNLOAD] 24. Chengguang Zhao#, Yuepiao Cai#, Xuzhi He, Jianling Li, Li Zhang, Jianzhang Wu, Yunjie Zhao, Shulin Yang, Xiaokun Li, Wulan Li*, Guang Liang*. Synthesisand anti-inflammatory evaluation of novel mono-carbonyl analogues of curcumin in LPS-stimulated RAW 264.7 macrophages, Eur J Med Chem, 2010, 45: 5773-5780.(二区，IF = 3.26)[PDF DOWNLOAD] 23. Chengguang Zhao#, Ju Yang#, Yi Wang, Donglou Liang, Xuyi Yang, Xiaoxia Li, Jianzhang Wu, Xiaoping Wu, Shulin Yang, Xiaokun Li, Guang Liang*. Synthesis of mono-carbonyl analogues of curcuminand their effects on inhibition of cytokine release in LPS-stimulated RAW 264.7 macrophages, Bioorg. Med. Chem., 2010, 18: 2388-2393. (三区，IF = 3.1)[PDF DOWNLOAD] 22. Renshan Ge, Yi Huang, Guang Liang*, Xiaokun Li. 11β-hydroxysteroid dehydrogenase type 1 inhibitors as promising therapeutic drugs for diabetes: statusand development. Curr Med Chem, 2010, 17: 412-422. (二区，IF = 4.89)[PDF DOWNLOAD] 20. Xiao J, Tan Y, Pan Y, Liang G, Qu C, Zhang X, Zhang Y, Li X*, Yang H*. A New Cyclooxygenase-2 Inhibitor,(1E, 4E)-1, 5-Bis (2-bromophenyl) penta-1, 4-dien-3-one (GL63) Suppresses Cyclooxygenase-2 Gene Expression in Human Lung Epithelial Cancer Cells: Coupled mRNA Stabilizationand Posttranscriptional Inhibition. Biologicaland Pharmaceutical Bulletin,2010, 33, (7), 1170-1175.(四区，IF=1.81)[PDF DOWNLOAD] 19. Chen X, Tang LJ, Sun YN, Qiu PH*, Liang G. Syntheses, characterizationand antitumor activities of transition metal complexes with isoflavone. J Inorg Biochem. 2010, 104(4): 379-84. (三区，IF=3.25)[PDF DOWNLOAD] 18. Xiao J#, Chu Y#, Hu K, Wan J, Huang Y, Jiang C, Liang G, Li X*. Synthesisand biological analysis of a new curcumin analogue for enhanced anti-tumor activity in HepG 2 cells. Oncol Rep，2010, 23, (5), 1435-41.(四区，IF=1.524)[PDF DOWNLOAD] 17.Guo-Xin Hu#, Ling Guang#, Yanhui Chu, Xiaokun Li, Qing-Quang Lian*, Han Lin, Yi He, Yadong Huang, Dianne O. Hardy, Ren-Shan Ge*. Curcumin derivatives inhibit testicular 17b-hydroxysteroid dehydrogenase 3, Bioorg. Med. Chem. Lett., 2010, 20: 2549-2551. (三区，IF = 2.6)[PDF DOWNLOAD] 16. Weibin Zha, Guang Liang, Jian Xiao, Elaine J. Studer, Phillip B. Hylemon, William M. Pandak, Guangji Wang*, Xiaokun Li, Huiping Zhou*. Berberine Inhibits HIV Protease Inhibitor-Induced Inflammatory Response by Modulating ER Stress Signaling Pathways in Murine Macrophages, PLoS One, 2010, 5(2): e9069 (二区，IF = 4.4)[PDF DOWNLOAD] 13. Guang Liang, Huiping Zhou, Yi Wang, Biao Feng, Jian Xiao, Li Chen, EmilyC.Gurley,Shulin Yang*, Xiaokun Li*. Inhibition of LPS-induced Production of Inflammatory Factors in the Macrophages by Mono-carbonyl Analogues of Curcumin. Journal of Cellularand Molecular Medicine, 2009, 13(9B):3370-9. （二区，IF=5.1）[PDF DOWNLOAD] 12. Cheng-Guang Zhao, Ju Yang, Yi Huang, Guang Liang*(Corresponding)and Xiao-Kun Li. Crystal structure of ortho-(2E,5E)-2,5-bis(2-methoxybenzylidene) cyclopentanone, C21H20O3. Z. Kristallogr. NCS, 224 (2009) 337-338[PDF DOWNLOAD] 11. Li Chen#, Sirikalaya Jarujaron#, Xudong Wu, Lixin Sun, Weibin Zha, Guang Liang, Xuan Wang, Emily C. Gurley, Elaine J. Studer, Phillip B. Hylemon, William M. Pandak Jr., Luyong Zhang, Guangji Wang, Xiaokun Li, Paul Dent, Huiping Zhou*. HIV protease inhibitor lopinavir-induced TNF-αand IL-6 expression is coupled to the unfolded protein responseand ERK signaling pathways in macrophages. Biochemical Pharmacology, 2009, 78: 70-77.(二区，IF=4.889)[PDF DOWNLOAD] 10. Guang Liang, Lili Shao, Yi Wang, Chengguang Zhao, Yanhui Chu, Jian Xiao, Yu Zhao, Xiaokun Li*, Shulin Yang*. Explorationand synthesis of curcumin analogues with improved structural stability both in vitroand in vivo as cytotoxic agents. Bioorg. Med. Chem., 2009, 17: 2623-2631. (三区，IF=3.1)[PDF DOWNLOAD] 9. Guang Liang, Shulin Yang, Lili Shao, Yu Zhao, Cheng-Guang Zhao, Ju Yang, Yanxia Lv, Jian Xiao, , Xiaokun Li*. Synthesis, structure,and bioevaluation of 2,5-bis(arylmethenyl)cyclopentanones. Journal of Asian Natural Products Research, 2008, 10(10), 957-965.(四区，IF=0.8)[PDF DOWNLOAD] 7. Guang Liang, Shulin Yang, Jiang Xiao, Zhifeng Huang, Kexin Huang, Lili Shao, Huiping ZhouXiaokun Li*. Synthesis,crystal structureand anti-inflammatory properties of curcumin analogues. European Journal of Medicinal Chemistry, 2009, 44: 915-919 (二区，IF=2.3)[PDF DOWNLOAD] 6. Guang Liang, Xiaokun Li*, Li Chen, Shulin Yang, Xudong Wu, Elaine Studer, Emily Gurley, Phillip B. Hylemon, Faqing Ye, Yueru Li,and Huiping Zhou*. Synthesisand anti-inflammatory activities of mono-carbonyl analogues of curcumin, Bioorg. Med. Chem. Lett., 2008, 18(2), 1525-1529.(三区，IF=2.6)[PDF DOWNLOAD] 5. Guang Liang, Shulin Yang, Lijuan Jiang, Yu Zhao, Lili Shao, Jian Xiao, Faqing Ye, Yueru Li, Xiaokun Li*. Synthesisand anti-bacterial properties of mono-carbonyl analogues of curcumin, Chem. Pharm. Bull, 2008, 56(2), 162-167.(四区，IF=1.3)[PDF DOWNLOAD] 4. Guang Liang, Shu-Lin Yang, Xiao-HuiWang, Yue-Ru Liand Xiao-Kun Li*. (2E,6E)- 2,6-Bis[(5-methylthiophen-2-yl)methylene]cyclohexanone, Acta Cryst. (2007). E63, o4118. (四区，IF=0.58)[PDF DOWNLOAD]